Drug delivery to the central nervous system (CNS) is a tremendous challenge for academia and industry. The need for new treatments of brain diseases is growing with the increasing lifespan of western populations. Drug transport across the brain endothelium forming the blood-brain barrier (BBB) is a particularly great challenge because of the low intrinsic permeability of the barrier to most solutes and the presence of active efflux transporters.
Our multidisciplinary research program combines investigation of drug transport systems with investigation of BBB function and the neurovascular unit (NVU), the cells closely associated with the brain endothelium. The aim of the Research Initiative is to provide the new tools necessary to design novel drug delivery systems for transport of drugs across the BBB. This Research Initiative started its activities in March 2014 and consists of five primary investigators (PIs).
The research at the Research Initiative on “Drug delivery to the brain and blood-brain barrier transport mechanisms” encompasses five specific work packages (WP):
WP1: Development of drug delivery systems, PI Thomas Andresen, DTU
WP2: In vitro investigations of brain endothelial cell receptor internalization and trafficking pathways, PI Morten S. Nielsen, AU,
WP3: In vivo monitoring of nanocarrier transport and therapy in the brain, PI Torben Moos, AAU
WP4: Signalling at the NVU and BBB control, PI Martin Lauritzen, KU
WP5: In vitro models of the neurovascular unit, PI Birger Brodin, KU
Welcome to WP6
Sep 27, 2018
RIBBDD has the pleasure of welcoming professor Kristian Strømgaard and his group...
Sep 26, 2018
The RIBBDD network just received the wonderful news that...
9th RIBBDD biannual meeting
Jul 03, 2018
On May 17-18th, participants from the RIBBDD network met for the 9th biannual RIBBDD meeting...
New professor in the RIBBDD initiative
May 02, 2018
Birger Brodin has been appointed professor...
PhD defense: Sofie Hørlyck
Dec 11, 2017
Sofie Hørlyck will defend her PhD thesis...