1. Kristensen M, Brodin B. Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors.  J Pharm Sci In press.
  2. York-Duran MJ, Godoy-Gallardo M, Labay C, Urquhart AJ, Andresen TL, Hosta-Rigau L. Recent advances in compartmentalized synthetic architectures as drug carriers, cell mimics and artificial organelles. Colloids Surf B Biointerfaces. 2017;152:199-213.
  3. Xiang J, Routhe LJ, Andrew Wilkinson D, Hua Y, Moos T, Xi G, Keep RF. The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury. Fluids and barriers of the CNS. 2017;14(1):8.
  4. Thomsen MS, Birkelund S, Burkhart A, Stensballe A, Moos T. Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier. J Neurochem. 2017;140(5):741-54.
  5. Siupka P, Hersom MN, Lykke-Hartmann K, Johnsen KB, Thomsen LB, Andresen TL, Moos T, Abbott NJ, Brodin B, Nielsen MS. Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells. J Cereb Blood Flow Metab. 2017:271678X17700665.
  6. Saaby L, Brodin B. A critical view on in vitro analysis of P-glycoprotein (P-gp) transport kinetics. Journal of pharmaceutical sciences. 2017.
  7. Kristensen K, Henriksen JR, Andresen TL. Applying Fluorescence Correlation Spectroscopy to Investigate Peptide-Induced Membrane Disruption. Methods in molecular biology. 2017;1548:159-80.
  8. Johnsen K, Burkhart A, Andresen T, Moos T, Thomsen L. The transferrin receptor as a target for drug delivery to the brain in nanomedicine.  . Javier O. Morales PG, editor: Springer; 2017.
  9. Howarth C, Sutherland B, Choi HB, Martin C, Lind BL, Khennouf L, LeDue JM, Pakan JM, Ko RW, Ellis-Davies G, Lauritzen M, Sibson NR, Buchan AM, MacVicar BA. A Critical Role for Astrocytes in Hypercapnic Vasodilation in Brain. J Neurosci. 2017;37(9):2403-14.
  10. Helms HC, Aldana BI, Groth S, Jensen MM, Waagepetersen HS, Nielsen CU, Brodin B. Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model. J Cereb Blood Flow Metab. 2017:271678X17690760.
  11. Burkhart A, Andresen TL, Aigner A, Thomsen LB, Moos T. Transfection of primary brain capillary endothelial cells for protein synthesis and secretion of recombinant erythropoietin: a strategy to enable protein delivery to the brain. Cell Mol Life Sci. 2017.
  12. Tornabene E, Brodin B. Stroke and Drug Delivery-In Vitro Models of the Ischemic Blood-Brain Barrier. Journal of pharmaceutical sciences. 2016;105(2):398-405.
  13. Saaby L, Helms HC, Brodin B. IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies. Mol Pharm. 2016;26651362
  14. Roursgaard M, Knudsen KB, Northeved H, Persson M, Christensen T, Kumar PE, Permin A, Andresen TL, Gjetting T, Lykkesfeldt J, Vesterdal LK, Loft S, Moller P. In vitro toxicity of cationic micelles and liposomes in cultured human hepatocyte (HepG2) and lung epithelial (A549) cell lines. Toxicol In Vitro. 2016;36:164-71.
  15. Petersen AL, Henriksen JR, Binderup T, Elema DR, Rasmussen PH, Hag AM, Kjaer A, Andresen TL. In vivo evaluation of PEGylated (6)(4)Cu-liposomes with theranostic and radiotherapeutic potential using micro PET/CT. European journal of nuclear medicine and molecular imaging. 2016;43(5):941-52.
  16. Nielsen C, Brodin B. Application of cell culture and tissue models for assessing drug transport. In  Analytical techniques in the pharmaceutical sciences. . Rades T, Mullertz A, editors2016.
  17. Kucharz K, Sondergaard Rasmussen I, Bach A, Stromgaard K, Lauritzen M. PSD-95 uncoupling from NMDA receptors by Tat- N-dimer ameliorates neuronal depolarisation in cortical spreading depression. J Cereb Blood Flow Metab. 2016:271678X16645595.
  18. Kristensen K, Urquhart AJ, Thormann E, Andresen TL. Binding of human serum albumin to PEGylated liposomes: insights into binding numbers and dynamics by fluorescence correlation spectroscopy. Nanoscale. 2016;8(47):19726-36.
  19. Klinger SC, Hojland A, Jain S, Kjolby M, Madsen P, Svendsen AD, Olivecrona G, Bonifacino JS, Nielsen MS. Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells. FEBS J. 2016;283(13):2476-93.
  20. Klauber TC, Sondergaard RV, Sawant RR, Torchilin VP, Andresen TL. Elucidating the role of free polycations in gene knockdown by siRNA polyplexes. Acta Biomater. 2016.
  21. Khennouf L, Gesslein B, Lind BL, van den Maagdenberg AM, Lauritzen M. Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1. Ann Neurol. 2016;80(2):219-32.
  22. Ke P, Sun H, Liu M, Su Z, Hu K, Zhua H, Guo H, Sun H, Andresen TL, Olsen LF. Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide. IET Nanobiotechnol. 2016;10(1):8-12.
  23. Johnsen KB, Moos T. Revisiting nanoparticle technology for blood-brain barrier transport: Unfolding at the endothelial gate improves the fate of transferrin receptor-targeted liposomes. Journal of controlled release : official journal of the Controlled Release Society. 2016;222:32-46.
  24. Humle N, Johnsen KB, Arendt GA, Nielsen RP, Moos T, Thomsen LB. Targeted Vascular Drug Delivery in Cerebral Cancer. Curr Pharm Des. 2016;22(35):5487-504.
  25. Hersom M, Helms HC, Pretzer N, Goldeman C, Jensen AI, Severin G, Nielsen MS, Holm R, Brodin B. Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers. Mol Cell Neurosci. 2016;76:59-67.
  26. Helms HC, Abbott NJ, Burek M, Cecchelli R, Couraud PO, Deli MA, Forster C, Galla HJ, Romero IA, Shusta EV, Stebbins MJ, Vandenhaute E, Weksler B, Brodin B. In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. J Cereb Blood Flow Metab. 2016;26868179.
  27. Gaharwar AK, Arpanaei A, Andresen TL, Dolatshahi-Pirouz A. 3D Biomaterial Microarrays for Regenerative Medicine: Current State-of-the-Art, Emerging Directions and Future Trends. Advanced materials. 2016;28(4):771-81.
  28. Frellsen AF, Hansen AE, Jolck RI, Kempen PJ, Severin GW, Rasmussen PH, Kjaer A, Jensen AT, Andresen TL. Mouse Positron Emission Tomography Study of the Biodistribution of Gold Nanoparticles with Different Surface Coatings Using Embedded Copper-64. ACS nano. 2016;10(11):9887-98.
  29. Eigenmann DE, Durig C, Jahne EA, Smiesko M, Culot M, Gosselet F, Cecchelli R, Helms HC, Brodin B, Wimmer L, Mihovilovic MD, Hamburger M, Oufir M. In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV. 2016;103:118-26.
  30. Burkhart A, Skjorringe T, Johnsen KB, Siupka P, Thomsen LB, Nielsen MS, Thomsen LL, Moos T. Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier. Molecular neurobiology. 2016;53(10):7237-53.
  31. Bak M, Jolck RI, Eliasen R, Andresen TL. Affinity Induced Surface Functionalization of Liposomes Using Cu-Free Click Chemistry. Bioconjug Chem. 2016;27(7):1673-80.
  32. Zhang M, Sondergaard RV, Kumar EK, Henriksen JR, Cui D, Hammershoj P, Clausen MH, Andresen TL. A hydrogel based nanosensor with an unprecedented broad sensitivity range for pH measurements in cellular compartments. The Analyst. 2015;140(21):7246-53.
  33. Wolff A, Antfolk M, Brodin B, Tenje M. In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches. Journal of pharmaceutical sciences. 2015;104(9):2727-46.
  34. Thomsen MS, Andersen MV, Christoffersen PR, Jensen MD, Lichota J, Moos T. Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons. Neurobiology of disease. 2015;81:108-18.
  35. Thomsen LB, Burkhart A, Moos T. A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes. PloS one. 2015;10(8):e0134765.
  36. Sondergaard RV, Christensen NM, Henriksen JR, Kumar EK, Almdal K, Andresen TL. Facing the Design Challenges of Particle-Based Nanosensors for Metabolite Quantification in Living Cells. Chemical reviews. 2015;115(16):8344-78.
  37. Skjorringe T, Burkhart A, Johnsen KB, Moos T. Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology. Front Mol Neurosci. 2015;8:19.
  38. Saaby L, Tfelt-Hansen P, Brodin B. The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1. Pharmacology research & perspectives. 2015;3(4):e00151.
  39. Nyegaard M, Rendtorff ND, Nielsen MS, Corydon TJ, Demontis D, Starnawska A, Hedemand A, Buniello A, Niola F, Overgaard MT, Leal SM, Ahmad W, Wikman FP, Petersen KB, Cruger DG, Oostrik J, Kremer H, Tommerup N, Frodin M, Steel KP, Tranebjaerg L, Borglum AD. A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment. PLoS Genet. 2015;11(7):e1005386.
  40. La Rosa LR, Perrone L, Nielsen MS, Calissano P, Andersen OM, Matrone C. Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction. Front Cell Neurosci. 2015;9:109.
  41. Kristensen K, Henriksen JR, Andresen TL. Adsorption of cationic peptides to solid surfaces of glass and plastic. PloS one. 2015;10(5):e0122419.
  42. Kristensen K, Ehrlich N, Henriksen JR, Andresen TL. Single-vesicle detection and analysis of peptide-induced membrane permeabilization. Langmuir : the ACS journal of surfaces and colloids. 2015;31(8):2472-83.
  43. Klinger SC, Siupka P, Nielsen MS. Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters. Membranes. 2015;5(3):288-306.
  44. Jessen SB, Mathiesen C, Lind BL, Lauritzen M. Interneuron Deficit Associates Attenuated Network Synchronization to Mismatch of Energy Supply and Demand in Aging Mouse Brains. Cerebral cortex. 2015;26514162.
  45. Jessen SB, Brazhe A, Lind BL, Mathiesen C, Thomsen K, Jensen K, Lauritzen M. GABAA Receptor-Mediated Bidirectional Control of Synaptic Activity, Intracellular Ca2+, Cerebral Blood Flow, and Oxygen Consumption in Mouse Somatosensory Cortex In Vivo. Cerebral cortex. 2015;25(9):2594-609.
  46. Henriksen JR, Petersen AL, Hansen AE, Frankaer CG, Harris P, Elema DR, Kristensen AT, Kjaer A, Andresen TL. Remote Loading of (64)Cu(2+) into Liposomes without the Use of Ion Transport Enhancers. ACS applied materials & interfaces. 2015;7(41):22796-806.
  47. Hansen AE, Petersen AL, Henriksen JR, Boerresen B, Rasmussen P, Elema DR, Rosenschold PM, Kristensen AT, Kjaer A, Andresen TL. Positron Emission Tomography Based Elucidation of the Enhanced Permeability and Retention Effect in Dogs with Cancer Using Copper-64 Liposomes. ACS nano. 2015;9(7):6985-95.
  48. Desler C, Frederiksen JH, Angleys M, Maynard S, Keijzers G, Fagerlund B, Mortensen EL, Osler M, Lauritzen M, Bohr VA, Rasmussen LJ. Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline. Mitochondrion. 2015;25:34-7.
  49. Caviglia C, Zor K, Montini L, Tilli V, Canepa S, Melander F, Muhammad HB, Carminati M, Ferrari G, Raiteri R, Heiskanen A, Andresen TL, Emneus J. Impedimetric toxicity assay in microfluidics using free and liposome-encapsulated anticancer drugs. Analytical chemistry. 2015;87(4):2204-12.
  50. Caviglia C, Zor K, Canepa S, Carminati M, Larsen LB, Raiteri R, Andresen TL, Heiskanen A, Emneus J. Interdependence of initial cell density, drug concentration and exposure time revealed by real-time impedance spectroscopic cytotoxicity assay. The Analyst. 2015;140(10):3623-9.
  51. Burkhart A, Thomsen LB, Thomsen MS, Lichota J, Fazakas C, Krizbai I, Moos T. Transfection of brain capillary endothelial cells in primary culture with defined blood-brain barrier properties. Fluids and barriers of the CNS. 2015;12:19.
  52. Burkhart A, Skjorringe T, Johnsen KB, Siupka P, Thomsen LB, Nielsen MS, Thomsen LL, Moos T. Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier. Molecular neurobiology. 2015;26687231.
  53. Bruun J, Larsen TB, Jolck RI, Eliasen R, Holm R, Gjetting T, Andresen TL. Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood-brain barrier and glioma cells. International journal of nanomedicine. 2015;10:5995-6008.
  54. Ayata C, Lauritzen M. Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiological reviews. 2015;95(3):953-93.
  55. Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, Ernst JA, Scearce-Levie K, Couch JA, Dennis MS, Watts RJ. Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates. Sci Transl Med. 2014;6(261):261ra154.
  56. Viart HM, Larsen TS, Tassone C, Andresen TL, Clausen MH. Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media. Chemical communications. 2014;50(58):7800-2.
  57. Sondergaard RV, Henriksen JR, Andresen TL. Design, calibration and application of broad-range optical nanosensors for determining intracellular pH. Nature protocols. 2014;9(12):2841-58.
  58. Kristensen K, Henriksen JR, Andresen TL. Quantification of leakage from large unilamellar lipid vesicles by fluorescence correlation spectroscopy. Biochimica et biophysica acta. 2014;1838(12):2994-3002.
  59. Knudsen KB, Northeved H, Gjetting T, Permin A, Andresen TL, Wegener KM, Lam HR, Lykkesfeldt J. In vivo distribution of cationic Rhodamine B fluorescent nanoparticles in the rat. . J Nanopart Res 2014;16(2):1-11.
  60. Knudsen KB, Northeved H, Ek PK, Permin A, Andresen TL, Larsen S, Wegener KM, Lam HR, Lykkesfeldt J. Differential toxicological response to positively and negatively charged nanoparticles in the rat brain. Nanotoxicology. 2014;8(7):764-74.
  61. Jensen AI, Binderup T, Kumar EP, Kjaer A, Rasmussen PH, Andresen TL. Positron emission tomography based analysis of long-circulating cross-linked triblock polymeric micelles in a U87MG mouse xenograft model and comparison of DOTA and CB-TE2A as chelators of copper-64. Biomacromolecules. 2014;15(5):1625-33.
  62. Helms HCC, Uhd NC, Brodin B. Glutamate efflux at the blood-brain barrier: cellular mechanisms and potential clinical relevance. Archives of medical research. 2014;45(8):639-45.
  63. Helms HC, Hersom M, Kuhlmann LB, Badolo L, Nielsen CU, Brodin B. An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1. The AAPS journal. 2014;16(5):1046-55.
  64. Helms HC, Brodin B. Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes. Methods in molecular biology. 2014;1135:365-82.
  65. Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell D. Capillary pericytes regulate cerebral blood flow in health and disease. Nature. 2014;508(7494):55-60.
  66. Gjetting T, Jolck RI, Andresen TL. Effective nanoparticle-based gene delivery by a protease triggered charge switch. Advanced healthcare materials. 2014;3(7):1107-18.
  67. Burkhart A, Azizi M, Thomsen MS, Thomsen LB, Moos T. Accessing targeted nanoparticles to the brain: the vascular route. Current medicinal chemistry. 2014;21(36):4092-9.
  68. Brazhe A, Mathiesen C, Lind B, Rubin A, Lauritzen M. Multiscale vision model for event detection and reconstruction in two-photon imaging data. Neurophotonics. 2014;1(1):011012.
  69. Ballet S, Betti C, Novoa A, Tomboly C, Nielsen CU, Helms HC, Lesniak A, Kleczkowska P, Chung NN, Lipkowski AW, Brodin B, Tourwe D, Schiller PW. In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt-DALDA Analogues. ACS medicinal chemistry letters. 2014;5(4):352-7.