Work Package 1
Development of drug delivery systems
Principal Investigator: Thomas Andresen, Department of Micro- and Nanotechnology, Technical University of Denmark
We are focused on developing innovative new solutions for transporting macromolecules into the brain and studying their distribution. Particularly we are focused on:
- Research in nanocarrier systems for targeting the blood brain barrier
- Research in nanocarrier systems that are sensitive to the microenvironment inside the brain endothelial cells or brain interstitium, obtaining target specific drug release
- Development of new regiospecific conjugation chemistries for antibodies
- Synthesis of new drug delivery carrier materials
- Synthesis of new reporter molecules for investigating biodistribution and transport of macromolecules and nanocarriers in brain
- Novel gene delivery systems for obtaining gene silencing or expression in brain endothelium
- Understanding the role of protein adsorption to nanocarriers in relation to their biodistribution and pharmacokinetics
- Characterization of nanocarrier systems in biological systems by electron microscopy
- Investigating the role of glycocalyx in nanocarrier transport by electron microscopy
- Optimization of pathological models for testing nanocarrier systems, including brain cancer.
|Thomas L. Andresen||Professoremail@example.com|
|Casper Hempel||Assistant Professorfirstname.lastname@example.org|
|Kasper Bendix Johnsen||PostDocemail@example.com|
|Sara Björk Sigurdardóttir||PhD firstname.lastname@example.org|
|Martin Bak||PhD email@example.com|
|Serhii Kostrikov||PhD firstname.lastname@example.org|
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