Work Package 1

Development of drug delivery systems

Principal Investigator: Thomas Andresen, Department of Micro- and Nanotechnology, Technical University of Denmark

We are focused on developing innovative new solutions for transporting macromolecules into the brain and studying their distribution. Particularly we are focused on:

Research in nanocarrier systems for targeting the blood brain barrier
Research in nanocarrier systems that are sensitive to the microenvironment inside the brain endothelial cells or brain interstitium, obtaining target specific drug release
Development of new regiospecific conjugation chemistries for antibodies
Synthesis of new drug delivery carrier materials
Synthesis of new reporter molecules for investigating biodistribution and transport of macromolecules and nanocarriers in brain
Novel gene delivery systems for obtaining gene silencing or expression in brain endothelium
Understanding the role of protein adsorption to nanocarriers in relation to their biodistribution and pharmacokinetics
Characterization of nanocarrier systems in biological systems by electron microscopy
Investigating the role of glycocalyx in nanocarrier transport by electron microscopy
Optimization of pathological models for testing nanocarrier systems, including brain cancer.