Work Package 2
In vitro investigations of brain endothelial cell receptor internalization and trafficking pathways
Principal Investigator: Morten Schallburg Nielsen, Department of Biomedicine, Aarhus University
This work package deals with analysis of the receptor-mediated transport systems in brain endothelial cells, which have the potential to mediate transcytosis of nanocarriers and antibodies. Previous studies using the Transferrin receptor and LRP1 (Low density lipoprotein receptor-related protein1) have succeeded in transporting drugs across the endothelium.
In this work we will characterize different subcellular trafficking routes of known and novel receptors in brain endothelial cells. Currently, we are focusing on the recycling receptor Transferrin receptor and the retrograde transported mannose-6-phosphate receptor. The work will furthermore include a detailed classification of the endo-lysosomal system and functional internalization mechanisms in in vitro models of the blood-brain barrier.
The aim is to understand the receptor-mediated transcytosis mechanism in details in order to select the optimal receptor system for drug delivery to the brain.
Our studies are primarily based on state-of-the-art imaging systems such as confocal, spinning disk, high content screening and TIRF microscopy in combination with in vitro blood-brain barrier models.
|Morten Schallburg Nielsen||Professorfirstname.lastname@example.org|
|Susanne Trillingsgaard Venø||PostDocemail@example.com|
9th RIBBDD biannual meeting
Jul 03, 2018
On May 17-18th, participants from the RIBBDD network met for the 9th biannual RIBBDD meeting...
New professor in the RIBBDD initiative
May 02, 2018
Birger Brodin has been appointed professor...
PhD defense: Sofie Hørlyck
Dec 11, 2017
Sofie Hørlyck will defend her PhD thesis...
8th RIBBDD biannual meeting
Nov 14, 2017
On October 23-24th 2017, the 8th RIBBDD biannual meeting took place...
Portraits of young scientists
Sep 29, 2017
New series of portraits of our talented young scientists...
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