Work Package 3
In vivo monitoring of nanocarrier transport and therapy in the brain
Principal Investigator: Torben Moos, Laboratory of Neurobiology, Department of Health Science and Technology, Aalborg University
- We investigate uptake and transport of nanocarriers across the BBB in vitro using blood brain barrier models based on primary cells isolated form rats, mice, and pigs.
- We investigate uptake and transport of nanocarriers at the brain capillaries and their transport further into the post capillary compartments in vivo using rodent models. The animal models are normal rats and mice, rats surgically operated to induce a chronic neurodegeneration, transgenic mice containing amyloid deposits, and nude mice with gliablastoma.
- We investigate the influence of the basement membrane as a limiting factor for nanocarrier transport at the BBB and changes of the basement membrane in neurodegenerative diseases.
- We investigate protein expression and secretion of recombinant proteins into the brain parenchyma, after viral and non-viral gene therapy to the brain capillary endothelium using in vitro BBB models and in vivo animal models. We explore this as a novel recombinant protein delivery strategy for the treatment of neurodegenerative and lysosomal storage diseases.
|Maj Schneider Thomsen||Assistant Professoremail@example.com|
|Hanne Krone Nielsen||Technicianfirstname.lastname@example.org|
|Charlotte Laurfelt Munch Jacobsen||PhD email@example.com|
|Steinunn Helgadottir||Research Assistantfirstname.lastname@example.org|
RIBBDD biannual meeting, November 2018
Dec 03, 2018
On November 28-29th, 48 researchers from the RIBBDD network gathered at University...
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RIBBDD has the pleasure of welcoming professor Kristian Strømgaard and his group...
Sep 26, 2018
The RIBBDD network just received the wonderful news that...
9th RIBBDD biannual meeting
Jul 03, 2018
On May 17-18th, participants from the RIBBDD network met for the 9th biannual RIBBDD meeting...
New professor in the RIBBDD initiative
May 02, 2018
Birger Brodin has been appointed professor...
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