Work Package 3
In vivo monitoring of nanocarrier transport and therapy in the brain
Principal Investigator: Torben Moos, Laboratory of Neurobiology, Department of Health Science and Technology, Aalborg University
- We investigate uptake and transport of nanocarriers across the BBB in vitro using blood brain barrier models based on primary cells isolated form rats, mice, and pigs.
- We investigate uptake and transport of nanocarriers at the brain capillaries and their transport further into the post capillary compartments in vivo using rodent models. The animal models are normal rats and mice, rats surgically operated to induce a chronic neurodegeneration, transgenic mice containing amyloid deposits, and nude mice with gliablastoma.
- We investigate the influence of the basement membrane as a limiting factor for nanocarrier transport at the BBB and changes of the basement membrane in neurodegenerative diseases.
- We investigate protein expression and secretion of recombinant proteins into the brain parenchyma, after viral and non-viral gene therapy to the brain capillary endothelium using in vitro BBB models and in vivo animal models. We explore this as a novel recombinant protein delivery strategy for the treatment of neurodegenerative and lysosomal storage diseases.
|Maj Schneider Thomsen||Assistant Professorfirstname.lastname@example.org|
|Hanne Krone Nielsen||Technicianemail@example.com|
|Charlotte Laurfelt Munch Jacobsen||PhD firstname.lastname@example.org|
|Steinunn Helgadottir||Research Assistantemail@example.com|
9th RIBBDD biannual meeting
Jul 03, 2018
On May 17-18th, participants from the RIBBDD network met for the 9th biannual RIBBDD meeting...
New professor in the RIBBDD initiative
May 02, 2018
Birger Brodin has been appointed professor...
PhD defense: Sofie Hørlyck
Dec 11, 2017
Sofie Hørlyck will defend her PhD thesis...
8th RIBBDD biannual meeting
Nov 14, 2017
On October 23-24th 2017, the 8th RIBBDD biannual meeting took place...
Portraits of young scientists
Sep 29, 2017
New series of portraits of our talented young scientists...
There are no upcoming events at this time.
All RIBBDD members are highly encourage to actively participate in external events to broader their knowledge