Work Package 3
In vivo monitoring of nanocarrier transport and therapy in the brain
Principal Investigator: Torben Moos, Laboratory of Neurobiology, Department of Health Science and Technology, Aalborg University
- We investigate uptake and transport of nanocarriers across the BBB in vitro using blood brain barrier models based on primary cells isolated form rats, mice, and pigs.
- We investigate uptake and transport of nanocarriers at the brain capillaries and their transport further into the post capillary compartments in vivo using rodent models. The animal models are normal rats and mice, rats surgically operated to induce a chronic neurodegeneration, transgenic mice containing amyloid deposits, and nude mice with gliablastoma.
- We investigate the influence of the basement membrane as a limiting factor for nanocarrier transport at the BBB and changes of the basement membrane in neurodegenerative diseases.
- We investigate protein expression and secretion of recombinant proteins into the brain parenchyma, after viral and non-viral gene therapy to the brain capillary endothelium using in vitro BBB models and in vivo animal models. We explore this as a novel recombinant protein delivery strategy for the treatment of neurodegenerative and lysosomal storage diseases.
|Maj Schneider Thomsen||Assistant firstname.lastname@example.org|
|Lisa Juul Routhe||PostDocemail@example.com|
|Eva Hede Olsen||PhD firstname.lastname@example.org|
|Hanne Krone Nielsen||Technicianemail@example.com|
|Charlotte Laurfelt Munch Jacobsen||PhD firstname.lastname@example.org|
|Steinunn Helgadottir||PhD student
|Betül Hiz Saroglu||Research email@example.com|
PhD defence: Sarah Christine Christensen
May 06, 2020
Sarah Christine Christensen will defend her PhD thesis...
PhD defence: Nikolay Kutuzov
Jan 07, 2020
Nikolay Kutuzov will defend his PhD thesis...
Søren Grubb wins the “Best Presentation Award”
Nov 28, 2019
Søren Grubb, Assistant Professor from Martin Lauritzen Lab, received the “Best Presentation Award”...
RIBBDD BIANNUAL MEETING, NOVEMBER 2019
Nov 21, 2019
November 19-20, 45 members from the RIBBDD network met at The Mærsk Tower in Copengahen...
PhD defence: Charlotte Goldeman Andersen
Jul 02, 2019
Charlotte Goldeman Andersen will defend her PhD theisis...
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