Work Package 3
In vivo monitoring of nanocarrier transport and therapy in the brain
Principal Investigator: Torben Moos, Laboratory of Neurobiology, Department of Health Science and Technology, Aalborg University
- We investigate uptake and transport of nanocarriers across the BBB in vitro using blood brain barrier models based on primary cells isolated form rats, mice, and pigs.
- We investigate uptake and transport of nanocarriers at the brain capillaries and their transport further into the post capillary compartments in vivo using rodent models. The animal models are normal rats and mice, rats surgically operated to induce a chronic neurodegeneration, transgenic mice containing amyloid deposits, and nude mice with gliablastoma.
- We investigate the influence of the basement membrane as a limiting factor for nanocarrier transport at the BBB and changes of the basement membrane in neurodegenerative diseases.
- We investigate protein expression and secretion of recombinant proteins into the brain parenchyma, after viral and non-viral gene therapy to the brain capillary endothelium using in vitro BBB models and in vivo animal models. We explore this as a novel recombinant protein delivery strategy for the treatment of neurodegenerative and lysosomal storage diseases.
|Maj Schneider Thomsen||Assistant email@example.com|
|Lisa Juul Routhe||PostDocfirstname.lastname@example.org|
|Eva Hede Olsen||PhD email@example.com|
|Hanne Krone Nielsen||Technicianfirstname.lastname@example.org|
|Charlotte Laurfelt Munch Jacobsen||PhD email@example.com|
|Steinunn Helgadottir||PhD student
|Betül Hiz Saroglu||Research firstname.lastname@example.org|
PhD defence: Charlotte Goldeman Andersen
Jul 02, 2019
Charlotte Goldeman Andersen will defend her PhD theisis...
RIBBDD biannual meeting, April 2019
May 10, 2019
On April 23-24, almost 50 members from the RIBBDD network met at Helnan Marselis Hotel in Aarhus...
RIBBDD biannual meeting, November 2018
Dec 03, 2018
On November 28-29th, 48 researchers from the RIBBDD network gathered at University...
Welcome to WP6
Sep 27, 2018
RIBBDD has the pleasure of welcoming professor Kristian Strømgaard and his group...
Sep 26, 2018
The RIBBDD network just received the wonderful news that...