Work Package 5
In vitro models of the neurovascular unit
Principal Investigator: Birger Brodin, Drug Transporters in ADME, Department of Pharmacy, University of Copenhagen
- Investigate receptor expression and receptor-mediated transport in bovine in vitro models of the blood-brain barrier.
- Investigation of blood-brain barrier permeability properties and localization of tight-junctions and receptors during oxygen-glucose deprivation (OGD)/reperfusion treatment, in both contact-coculture and monoculture in vitro
- Investigate intercellular communication in the neurovascular unit and in particular elucidate the role of ATP in activation of specific purinergic receptor types and changes in intracellular calcium levels in primary bovine pericytes.
- Generate and characterize an in vitro model of the blood-brain barrier using human induced pluripotent stem cells in co-culture with other cell types of the neurovascular unit, such as astrocytes and pericytes. Such a model would have a wide array of research opportunities and would be an important tool in testing e.g. active drug transport and cell-to-cell interactions at the blood-brain barrier.
|Hans Christian Cederberg Helms||Assistant Professoremail@example.com|
|Charlotte Goldeman Andersen||PhD firstname.lastname@example.org|
|Nana Isabella Svane||Scholar student|
|Mie Kristensen||Assistant Professoremail@example.com|
|Lasse Saaby||Research Assistantfirstname.lastname@example.org|
|Burak Ozgür||PhD email@example.com|
|Patrick Frøslev||Master's firstname.lastname@example.org|
|Emma Lisa Al Humaidan
|Mette Louise Sommer
|Thomas Bucholz||Master's student|
|Ahmed Al-Robai||Master's student|
|Sven Barbara Hinca||Master's student|
PhD defence: Charlotte Goldeman Andersen
Jul 02, 2019
Charlotte Goldeman Andersen will defend her PhD theisis...
RIBBDD biannual meeting, April 2019
May 10, 2019
On April 23-24, almost 50 members from the RIBBDD network met at Helnan Marselis Hotel in Aarhus...
RIBBDD biannual meeting, November 2018
Dec 03, 2018
On November 28-29th, 48 researchers from the RIBBDD network gathered at University...
Welcome to WP6
Sep 27, 2018
RIBBDD has the pleasure of welcoming professor Kristian Strømgaard and his group...
Sep 26, 2018
The RIBBDD network just received the wonderful news that...