Work Package 5
In vitro models of the neurovascular unit
Principal Investigator: Birger Brodin, Drug Transporters in ADME, Department of Pharmacy, University of Copenhagen
- Investigate receptor expression and receptor-mediated transport in bovine in vitro models of the blood-brain barrier.
- Investigation of blood-brain barrier permeability properties and localization of tight-junctions and receptors during oxygen-glucose deprivation (OGD)/reperfusion treatment, in both contact-coculture and monoculture in vitro
- Investigate intercellular communication in the neurovascular unit and in particular elucidate the role of ATP in activation of specific purinergic receptor types and changes in intracellular calcium levels in primary bovine pericytes.
- Generate and characterize an in vitro model of the blood-brain barrier using human induced pluripotent stem cells in co-culture with other cell types of the neurovascular unit, such as astrocytes and pericytes. Such a model would have a wide array of research opportunities and would be an important tool in testing e.g. active drug transport and cell-to-cell interactions at the blood-brain barrier.
|Hans Christian Cederberg Helms||Assistant Professorfirstname.lastname@example.org|
|Charlotte Goldeman Andersen||PhD email@example.com|
|Nana Isabella Svane||Scholar student|
|Mie Kristensen||Assistant Professorfirstname.lastname@example.org|
|Lasse Saaby||Research Assistantemail@example.com|
|Burak Ozgür||PhD firstname.lastname@example.org|
|Patrick Frøslev||Master's email@example.com|
|Emma Lisa Al Humaidan
|Mette Louise Sommer
|Thomas Bucholz||Master's student|
|Ahmed Al-Robai||Master's student|
|Sven Barbara Hinca||Master's student|
PhD defence: Sarah Christine Christensen
May 06, 2020
Sarah Christine Christensen will defend her PhD thesis...
PhD defence: Nikolay Kutuzov
Jan 07, 2020
Nikolay Kutuzov will defend his PhD thesis...
Søren Grubb wins the “Best Presentation Award”
Nov 28, 2019
Søren Grubb, Assistant Professor from Martin Lauritzen Lab, received the “Best Presentation Award”...
RIBBDD BIANNUAL MEETING, NOVEMBER 2019
Nov 21, 2019
November 19-20, 45 members from the RIBBDD network met at The Mærsk Tower in Copengahen...
PhD defence: Charlotte Goldeman Andersen
Jul 02, 2019
Charlotte Goldeman Andersen will defend her PhD theisis...
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